4EBP1 antibody

$300.00

  • Model: PAab10129
  • 50 Units in Stock
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4EBP1 antibody


Product Name 4EBP1 antibody

Catalog No PAab10129

Packing 100ul

Form liquid

Alternative Name 4E BP1, 4EBP1, BP 1, eIF4E binding protein 1, EIF4EBP1, PHAS I

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Eukaryotic translation initiation factor 4E-binding protein 1(4EBP1), is a member of 4EBPs family, which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E, thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors, hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1, alpha, beta and gamma.

Immunogen eukaryotic translation initiation factor 4E binding protein 1

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC, IF

Recommended dilution WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200

IHC use Immunohistochemistry of paraffin-embedded human breast cancer slide using PAab10129(4EBP1 Antibody) at dilution of 1:50


WB use

MCF7 cells were subjected to SDS PAGE followed by western blot with PAab10129(4EBP1 antibody) at dilution of 1:1000

Protein Information

Gene ID 1978

Uniprot ID Q13541

Calculated MW 17 kDa

Research Area Cancer, Metabolism

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