AIF1 antibody

$275.00

  • Model: PAab09944
  • 50 Units in Stock
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AIF1 antibody


Product Name AIF1 antibody

Catalog No PAab09944

Packing 100ul

Form liquid

Alternative Name AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.

Immunogen allograft inflammatory factor 1

Specificity Human, Mouse, Rat

Tested Application ELISA, WB

Recommended dilution WB: 1:500-1:2000

IHC use


WB use

U937 cells were subjected to SDS PAGE followed by western blot with PAab09944(AIF1 antibody) at dilution of 1:1000

Protein Information

Gene ID 199

Uniprot ID P55008

Calculated MW 16 kDa

Research Area Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells, Immunology

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