alpha-synuclein antibody


  • Model: PAab09891
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alpha-synuclein antibody

Product Name alpha-synuclein antibody

Catalog No PAab09891

Packing 100ul

Form liquid

Alternative Name Alpha synuclein, NACP, PARK1, PARK4, SNCA

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Immunogen synuclein, alpha (non A4 component of amyloid precursor)

Specificity Human, Mouse, Rat

Tested Application ELISA, IHC, WB

Recommended dilution WB: 1:500 - 1:2000; IHC: 1:500 - 1:2000

IHC use Immunohistochemistry of paraffin-embedded mouse brain using PAab09891(SNCA antibody) at dilution of 1:1000

WB use

mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab09891(SNCA antibody) at dilution of 1:1000

Protein Information

Gene ID 6622

Uniprot ID P37840

Calculated MW 23 kDa

Research Area Neuroscience

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