ARHGEF1 antibody


  • Model: PAab10091
  • 50 Units in Stock
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ARHGEF1 antibody

Product Name ARHGEF1 antibody

Catalog No PAab10091

Packing 100ul

Form liquid

Alternative Name ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5, ARHG1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Immunogen Rho guanine nucleotide exchange factor(GEF) 1

Specificity Human, Rat

Tested Application ELISA, IHC

Recommended dilution IHC: 1:20-1:200

IHC use Immunohistochemistry of paraffin-embedded rat lung using PAab10091(PER2 antibody) at dilution of 1:50

WB use

Protein Information

Gene ID 9138

Uniprot ID Q92888

Calculated MW 102-110 kDa

Research Area Signal Transduction, Metabolism

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