CASP3 antibody

$275.00

  • Model: PAab09938
  • 50 Units in Stock
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CASP3 antibody


Product Name CASP3 antibody

Catalog No PAab09938

Packing 100ul

Form liquid

Alternative Name Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.

Immunogen caspase 3, apoptosis-related cysteine peptidase

Specificity Human, Mouse, Rat

Tested Application ELISA, IHC, WB,IF

Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:300; IF: 1:50-1:200

IHC use Immunohistochemistry of paraffin-embedded human breast cancer using PAab09938(CASP3 antibody) at dilution of 1:200


WB use

Untreated and Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09938 (CASP3 antibody) at dilution of 1:3000

Protein Information

Gene ID 836

Uniprot ID P42574

Calculated MW 32-35 kDa, 19 kDa, 17 kDa

Research Area Cancer, Metabolism, Neuroscience

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