Caspase 1 antibody


  • Model: PAab10015
  • 50 Units in Stock
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Caspase 1 antibody

Product Name Caspase 1 antibody

Catalog No PAab10015

Packing 100ul

Form liquid

Alternative Name CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.

Immunogen caspase 1

Specificity Human, Mouse

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human stomach tissue slide using PAab10015(CASP1 Antibody) at dilution of 1:100

WB use

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with PAab10015(CASP1 antibody) at dilution of 1:1000

Protein Information

Gene ID 834

Uniprot ID P29466

Calculated MW 45-47 kDa, 30 kDa, 35 kDa

Research Area Signal Transduction, Metabolism, Cardiovascular, Neuroscience

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