Caspase 8 antibody

$275.00

  • Model: PAab10024
  • 50 Units in Stock
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Caspase 8 antibody


Product Name Caspase 8 antibody

Catalog No PAab10024

Packing 100ul

Form liquid

Alternative Name Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.

Immunogen caspase 8, apoptosis-related cysteine peptidase

Specificity Human, Mouse

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded mouse kidney using PAab10024(CASP8 antibody) at dilution of 1:100


WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab10024(CASP8 antibody) at dilution of 1:1000

Protein Information

Gene ID 841

Uniprot ID Q14790

Calculated MW 50-55 kDa, 25-32 kDa

Research Area Signal Transduction, Metabolism, cancer

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