CD206 antibody

Product Name CD206 antibody

Catalog No PAab09912

Packing 100ul

Form liquid

Alternative Name CD206, CLEC13D, Macrophage mannose receptor 1, Mannose receptor, mannose receptor, C type 1, MMR, MRC1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains(responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

Immunogen mannose receptor, C type 1

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC, IF

Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

IHC use Immunohistochemistry of paraffin-embedded human lung using PAab09912(CD206 antibody) at dilution of 1:100

WB use

Mouse liver were subjected to SDS PAGE followed by western blot with PAab09912(CD206 antibody) at dilution of 1:1000

Protein Information

Gene ID 4360

Uniprot ID P22897

Calculated MW 166 kDa

Research Area Neuroscience, Immunology