CTSC antibody

$275.00

  • Model: PAab09934
  • 50 Units in Stock
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CTSC antibody


Product Name CTSC antibody

Catalog No PAab09934

Packing 100ul

Form liquid

Alternative Name CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

Immunogen Cathepsin C

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

IHC use Immunohistochemistry of paraffin-embedded rat kidney tissue slide using PAab09934 (CTSC antibody) at dilution of 1:100


WB use

Hela cells were subjected to SDS PAGE followed by western blot with PAab09934 (CTSC antibody) at dilution of 1:1000

Protein Information

Gene ID 1075

Uniprot ID P53634

Calculated MW 70 kDa

Research Area Cell Division and Proliferation

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