E-cadherin antibody


  • Model: PAab10112
  • 50 Units in Stock
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E-cadherin antibody

Product Name E-cadherin antibody

Catalog No PAab10112

Packing 100ul

Form liquid

Alternative Name Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2b

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Immunogen cadherin 1, type 1, E-cadherin (epithelial)

Specificity Human

Tested Application ELISA, IHC, WB, IF

Recommended dilution WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab10112( E-cadherin Antibody) at dilution of 1:1000

WB use

A431 cells were subjected to SDS PAGE followed by western blot with PAab10112(E-cadherin antibody) at dilution of 1:3000

Protein Information

Gene ID 999

Uniprot ID P12830

Calculated MW 130 kDa

Research Area Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells

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