GAD1 antibody

$275.00

  • Model: PAab09843
  • 50 Units in Stock
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GAD1 antibody


Product Name GAD1 antibody

Catalog No PAab09843

Packing 100ul

Form liquid

Alternative Name FLJ45882, GAD, GAD 67, GAD1, GAD67, Glutamate decarboxylase 1, SCP

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Immunogen glutamate decarboxylase 1

Specificity Human, Mouse, Rat

Tested Application ELISA, WB

Recommended dilution WB: 1:500 - 1:2000

IHC use


WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09843( GAD1 Antibody) at dilution of 1:1000

Protein Information

Gene ID 2571

Uniprot ID Q99259

Calculated MW 348 kDa

Research Area Neuroscience, Stem Cells, Metabolism

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