HLA-G antibody


  • Model: PAab09952
  • 50 Units in Stock
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HLA-G antibody

Product Name HLA-G antibody

Catalog No PAab09952

Packing 100ul

Form liquid

Alternative Name HLA 6.0, HLA G, HLA G antigen, HLAG, HLA-G, MHC class I antigen G, MHC G

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). HLA-G is a non-classical MHC class I molecule with multiple immunoregulatory properties. HLA-G exhibits a restricted pattern of expression that includes placental extravillous trophoblasts at the maternal-fetal interface, where it abolishes maternal immune cell activity against fetus and establishes immune tolerance. Aberrant expression of HLA-G has been found in a variety of human neoplastic diseases. It plays an important role in the escape of tumor cells from immunosurveillance.

Immunogen MHC class I antigen G

Specificity Human

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:2000-1:10000; IHC: 1:50-1:200

IHC use Immunohistochemistry of paraffin-embedded human placenta tissue slide using PAab09952( HLA-G Antibody) at dilution of 1:200

WB use

human placenta tissue were subjected to SDS PAGE followed by western blot with PAab09952( HLA-G Antibody) at dilution of 1:5000

Protein Information

Gene ID 3135

Uniprot ID P17693

Calculated MW 38 kDa

Research Area Immunology

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