MAP3K3 antibody


  • Model: PAab09784
  • 50 Units in Stock
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MAP3K3 antibody

Product Name MAP3K3 antibody

Catalog No PAab09784

Packing 100ul

Form liquid

Alternative Name MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.

Immunogen mitogen-activated protein kinase kinase kinase 3

Specificity Human

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:200-1:2000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab09784(MAP3K3 Antibody) at dilution of 1:100

WB use

HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09784(MAP3K3 Antibody) at dilution of 1:300

Protein Information

Gene ID 4215

Uniprot ID Q99759

Calculated MW 74 kDa

Research Area Signal Transduction, Immunology

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