p65/RELA antibody


  • Model: PAab09875
  • 50 Units in Stock
Ask a question

Add to Cart: Min:  0 Units:  0

p65/RELA antibody

Product Name p65/RELA antibody

Catalog No PAab09875

Packing 100ul

Form liquid

Alternative Name NFKB 3, NFKB p65, NFKB3, p65, RELA, Transcription factor p65

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Nuclear factor k B(NF-kB) is a sequence-specific DNA-binding protein complex which regulates the expression of viral genomes, including the human immunodeficiency virus, and a variety of cellular genes, particularly those involved in immune and inflammatory responses. The members of the NF-Kb family in mammalian cells include the proto-oncogene c-Rel,p50/p105(NFkB1), p65(RelA), p52/p100(NFkB2), and RelB. All of these proteins share a conserved 300-amino acid region known as the Rel homology domain which is responsible for DNA binding, dimerization, and nuclear translocation of NF-Kb. The p65 subunit is a major component of NF-Kb complexes and is responsible for trans-activation. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. It associates with chromatin at the NF-kappa-B promoter region via association with DDX1.

Immunogen v-rel reticuloendotheliosis viral oncogene homolog A(avian)

Specificity Human, Rat

Tested Application ELISA, IHC, IF, WB

Recommended dilution WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

IHC use Immunohistochemistry of paraffin-embedded rat lung using PAab09875(p65 antibody) at dilution of 1:50

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab09875(p65 antibody) at dilution of 1:500

Protein Information

Gene ID 5970

Uniprot ID Q04206

Calculated MW 65 kDa

Research Area Metabolism, Immunology, Cancer, Stem Cells, Cell Division and Proliferation

No customer comments for the moment.

Add A Comment

Related Products


No products

Total $0.00

Prices don't include postage.