PARP1 antibody


  • Model: PAab09939
  • 50 Units in Stock
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PARP1 antibody

Product Name PARP1 antibody

Catalog No PAab09939

Packing 100ul

Form liquid

Alternative Name ADPRT, ADPRT 1, ADPRT1, pADPRT 1, PARP, PARP 1, PARP1, poly (ADP ribose) polymerase 1, Poly [ADP ribose] polymerase 1, Poly[ADP ribose] synthase 1, PPOL

Purification protein A+G purified

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly(ADP-ribosyl)ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis.

Immunogen poly (ADP-ribose) polymerase 1

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC, IF

Recommended dilution WB: 1:5000 - 1:30000; IHC: 1:100 - 1:1000; IF: 1:50 - 1:500

IHC use Immunohistochemistry of paraffin-embedded human breast cancer using PAab09939(PARP1 antibody) at dilution of 1:600

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab09939(PARP1 Antibody) at dilution of 1:20000

Protein Information

Gene ID 142

Uniprot ID P09874

Calculated MW 115 kDa, 89 kDa

Research Area Metabolism

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