PTEN antibody

$275.00

  • Model: PAab09821
  • 50 Units in Stock
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PTEN antibody


Product Name PTEN antibody

Catalog No PAab09821

Packing 100ul

Form liquid

Alternative Name MMAC1, TEP1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

Immunogen phosphatase and tensin homolog

Specificity Human, Mouse, Rat, Monkey

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

IHC use Immunohistochemistry of paraffin-embedded mouse brain slide using PAab09821( PTEN Antibody) at dilution of 1:100


WB use

Hela cells were subjected to SDS PAGE followed by western blot with PAab09821( PTEN Antibody) at dilution of 1:1000

Protein Information

Gene ID 5728

Uniprot ID P60484

Calculated MW 53 kDa

Research Area Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience, Stem Cells, Cell Division and Proliferation

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