RANKL antibody


  • Model: PAab09838
  • 50 Units in Stock
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RANKL antibody

Product Name RANKL antibody

Catalog No PAab09838

Packing 100ul

Form liquid

Alternative Name CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.

Immunogen tumor necrosis factor (ligand) superfamily, member 11

Specificity Human

Tested Application ELISA, WB

Recommended dilution WB: 1:1000-1:5000

IHC use

WB use

Hela cells were subjected to SDS PAGE followed by western blot with PAab09838(RANKL antibody) at dilution of 1:3000

Protein Information

Gene ID 8600

Uniprot ID O14788

Calculated MW 17 kDa

Research Area Immunology, Signal Transduction, Developmental biology

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