SMARCA4 antibody

Product Name SMARCA4 antibody

Catalog No PAab10044

Packing 100ul

Form liquid

Alternative Name ATP dependent helicase SMARCA4, BAF190, BAF190A, BRG1, BRG1 associated factor 190A, FLJ39786, hSNF2b, Protein brahma homolog 1, Protein BRG 1, SMARCA4, SNF2, SNF2 BETA, SNF2B, SNF2L4, SNF2LB, SWI2, Transcription activator BRG1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

SMARCA4, also named as BAF190A, BRG1, SNF2B and SNF2L4, belongs to the SNF2/RAD54 helicase family. SMARCA4 is a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It is a component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. It is also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor(VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Immunogen SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Specificity Human, Mouse

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

IHC use Immunohistochemistry of paraffin-embedded human lung cancer using PAab10044(SMARCA4 antibody) at dilution of 1:100

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab10044(SMARCA4 antibody) at dilution of 1:1000

Protein Information

Gene ID 6597

Uniprot ID P51532

Calculated MW 185 kDa

Research Area Epigenetics, Stem Cells, Metabolism