TLR4 antibody

Product Name TLR4 antibody

Catalog No PAab09837

Packing 100ul

Form liquid

Alternative Name ARMD10, CD284, hToll, TLR4, TOLL, toll like receptor 4

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2b

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Immunogen toll-like receptor 4

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:1000-1:8000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using PAab09837( TLR4 Antibody) at dilution of 1:200

WB use

RAW 264.7 cells were subjected to SDS PAGE followed by western blot with PAab09837( TLR4 Antibody) at dilution of 1:4000

Protein Information

Gene ID 7099

Uniprot ID O00206

Calculated MW 35 kDa

Research Area Neuroscience, Immunology, Signal Transduction, Developmental biology