TNF alpha antibody

Product Name TNF alpha antibody

Catalog No PAab09822

Packing 100ul

Form liquid

Alternative Name Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNF-a, TNFSF2, Tumor necrosis factor

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Immunogen tumor necrosis factor (TNF superfamily, member 2)

Specificity Human, Mouse, Rat

Tested Application ELISA, WB, IHC

Recommended dilution WB: 1:1000 - 1:2000; IHC: 1:50 - 1:100

IHC use Immunohistochemistry of paraffin-embedded human stomach tissue slide using PAab09822( TNF-a Antibody) at dilution of 1:100.

WB use

Hela cells were subjected to SDS PAGE followed by western blot with PAab09822( TNF-a Antibody) at dilution of 1:1000

Protein Information

Gene ID 7124

Uniprot ID P01375

Calculated MW 21 kDa

Research Area Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience