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MCP(monocyte chemoattractant protein-1) 单核细胞趋化蛋白-1

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MCP(monocyte chemoattractant protein-1)单核细胞趋化蛋白-1 Gene name: MCP,MCP-1/MCAF Monocyte chemoattractant protein-1 (monocyte chemotactic protein 1,MCP-1), also known as monocyte chemoattractant and activator (monoctye chemotactic and activating factor,MCAF), belonging to the C-C subtribe . MCP-1/MCAF was originally from human myeloid monocytic line THP-1 and glioma cell lines as well as LPS or PHA stimulation found in human PBMC culture supernatant. Body and body outside experiment are confirmed that MCP-1 on single nuclear cell has more activity, activated single nuclear cell and giant bite cell, makes its cell pulp within Ca2+ concentration increased, Super oxygen of produced and release, and release dissolved bacteria enzyme, raised single nuclear cell and giant bite cell stick attached molecular as Integrin family Beta 2 group and alpha 4 Molecular of expression and cell factor IL-1, and IL-6 of produced, activation of giant bite cell can inhibit tumor cell of growth. MCP is the Basophilic granulocyte chemotactic agent and activator, especially stimulating basophil degranulation and histamine-releasing more strongly. Combining the MCP-1 and MCP-1R-specific, this receptor is primarily distributed in mononuclear cells and myeloid progenitor cells and basophils, which belongs to the IL-8R family. Distribution of the Duffy Antigen on the surface of human red blood cells can also be combined with MCP-1. In serum and synovial fluid of patients with rheumatoid arthritis MCP-1 levels increased significantly in synovial tissue composed of macrophages to produce MCP-1, MCP-1 associated with the pathology of rheumatoid arthritis. When high cholesterol and arterial medial smooth muscle cells to produce high levels of MCP-1, monocyte adhesion to the infiltration of blood vessels and arteries. Kidney inflammation, IL-1-induced Glomerular cell MCP-1. When Hyperlipidemia, LDL and Glomerular cells and stimulate them to produce MCP-1, Chemokine monocyte in the infiltration. If you have any further inquiry please contact us: Copyright Nova lifetech Inc.

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