Store News

Monday 04 April, 2016 | RSS Feed

MCP(monocyte chemoattractant protein-1) 单核细胞趋化蛋白-1

by www.lifescience-market.com | post a comment

MCP(monocyte chemoattractant protein-1)单核细胞趋化蛋白-1 Gene name: MCP,MCP-1/MCAF Monocyte chemoattractant protein-1 (monocyte chemotactic protein 1,MCP-1), also known as monocyte chemoattractant and activator (monoctye chemotactic and activating factor,MCAF), belonging to the C-C subtribe . MCP-1/MCAF was originally from human myeloid monocytic line THP-1 and glioma cell lines as well as LPS or PHA stimulation found in human PBMC culture supernatant. Body and body outside experiment are confirmed that MCP-1 on single nuclear cell has more activity, activated single nuclear cell and giant bite cell, makes its cell pulp within Ca2+ concentration increased, Super oxygen of produced and release, and release dissolved bacteria enzyme, raised single nuclear cell and giant bite cell stick attached molecular as Integrin family Beta 2 group and alpha 4 Molecular of expression and cell factor IL-1, and IL-6 of produced, activation of giant bite cell can inhibit tumor cell of growth. MCP is the Basophilic granulocyte chemotactic agent and activator, especially stimulating basophil degranulation and histamine-releasing more strongly. Combining the MCP-1 and MCP-1R-specific, this receptor is primarily distributed in mononuclear cells and myeloid progenitor cells and basophils, which belongs to the IL-8R family. Distribution of the Duffy Antigen on the surface of human red blood cells can also be combined with MCP-1. In serum and synovial fluid of patients with rheumatoid arthritis MCP-1 levels increased significantly in synovial tissue composed of macrophages to produce MCP-1, MCP-1 associated with the pathology of rheumatoid arthritis. When high cholesterol and arterial medial smooth muscle cells to produce high levels of MCP-1, monocyte adhesion to the infiltration of blood vessels and arteries. Kidney inflammation, IL-1-induced Glomerular cell MCP-1. When Hyperlipidemia, LDL and Glomerular cells and stimulate them to produce MCP-1, Chemokine monocyte in the infiltration. If you have any further inquiry please contact us: sales@lifescience-market.com Copyright Nova lifetech Inc. www.lifescience-market.com





Other news for Monday 04 April, 2016


View all news for Monday 04 April, 2016 on one page




News for Sunday 03 April, 2016


View all news for Sunday 03 April, 2016 on one page




News archive

Cart  

No products

Total $0.00

Prices don't include postage.

Cart