Anti-Caspase 8 antibody
Product Name Anti-Caspase 8 antibody
Catalog No PAab01294
Packing 100ug
Form liquid
Alternative Name Apoptotic cysteine protease antibody, Apoptotic protease Mch 5 antibody, Casp 8 antibody, CASP8 antibody, Caspase 8 antibody, Caspase 8/p18 antibody, Caspase8 antibody, FADD like ICE antibody, FLICE antibody, ICE like apoptotic protease 5 antibody, MACH antibody, MCH5
Purification Protein A+G purification
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 66093-1-AP can recognize pro- and cleaved-caspase 8.
Immunogen caspase 8, apoptosis-related cysteine peptidase
Specificity Human
Tested Application ELISA,IHC,WB,IF,IP
Recommended dilution WB:1:500-1:5000;IP:1:200-1:2000;IHC:1:100-1:400;IF:1:50-1:500
IHC use
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Caspase 8 Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).
WB use
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab01294(CASP8 antibody) at dilution of 1:1000
Protein Information
Gene ID841
Uniprot ID Q14790
Calculated MW 30-60kDa
location