Anti-ESR2 antibody

Product Name Anti-ESR2 antibody

Catalog No PAab02867

Packing 100ug

Form liquid

Alternative Name ESTRB antibody, NR3A2

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Immunogen estrogen receptor 2 (ER beta)

Specificity Human,Mouse

Tested Application ELISA,WB

Recommended dilution

IHC use

WB use

Protein Information

Gene ID2100

Uniprot ID Q92731

Calculated MW

location