Anti-FGFR1 antibody

$300.00

  • Model: PAab03099
  • 50 Units in Stock
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Anti-FGFR1 antibody

Product Name Anti-FGFR1 antibody

Catalog No PAab03099

Packing 100ug

Form liquid

Alternative Name BFGFR antibody, CEK antibody, FGFBR antibody, FLG antibody, FLT2 antibody, HBGFR

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Immunogen fibroblast growth factor receptor 1

Specificity Human, Mouse

Tested Application ELISA,WB,IHC,FC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FGFR1 Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).

WB use

Y79 cells were subjected to SDS PAGE followed by western blot with PAab03099( FGFR1 Antibody) at dilution of 1:1000

Protein Information

Gene ID2260

Uniprot ID P11362

Calculated MW

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