Anti-FHIT antibody

$300.00

  • Model: PAab03108
  • 50 Units in Stock
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Anti-FHIT antibody

Product Name Anti-FHIT antibody

Catalog No PAab03108

Packing 100ug

Form liquid

Alternative Name

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Immunogen fragile histidine triad gene

Specificity Human

Tested Application ELISA,WB,IF,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human breast cancer slide using FHIT Antibody at dilution of 1:50

WB use

K-562 cells were subjected to SDS PAGE followed by western blot with PAab03108(FHIT antibody) at dilution of 1:500

Protein Information

Gene ID2272

Uniprot ID P49789

Calculated MW

location

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