Anti-IA-2/PTPRN antibody

$300.00

  • Model: PAab04093
  • 50 Units in Stock
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Anti-IA-2/PTPRN antibody

 

Product Name Anti-IA-2/PTPRN antibody

Catalog No PAab04093

Packing 100ug

Form liquid

Alternative Name

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

 

Background/ FUNCTION

IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

 

Immunogen protein tyrosine phosphatase, receptor type, N

Specificity Human

Tested Application ELISA,WB,IF,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using PTPRN Antibody at dilution of 1:400 heat mediated antigen retrieved with Tris-EDTA bufferpH9).

WB use

human brain tissue were subjected to SDS PAGE followed by western blot with PAab04093(PTPRN antibody) at dilution of 1:500

Protein Information

Gene ID5798

Uniprot ID Q16849

Calculated MW 105 kDa

location

Plasma membrane
Cell membrane  1 Publication; Single-pass type I membrane protein  By similarity
Endosome
Endosome  By similarity
Other locations
Membrane  By similarity; Single-pass type I membrane protein  By similarity
secretory vesicle membrane  1 Publication; Single-pass type I membrane protein  Curated
Perikaryon  By similarity
axon  By similarity
synapse  By similarity
Note: Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes.By similarity1 Publication
ICA512-transmembrane fragment :
Other locations
secretory vesicle membrane  By similarity
ICA512-cleaved cytosolic fragment :
Nucleus
Nucleus  1 Publication

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