Anti-KEAP1 antibody

$245.00

  • Model: PAab04517
  • 50 Units in Stock
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Anti-KEAP1 antibody

Product Name Anti-KEAP1 antibody

Catalog No PAab04517

Packing 100ug

Form liquid

Alternative Name INRF2 antibody, KIAA0132 antibody, KLHL19

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Immunogen kelch-like ECH-associated protein 1

Specificity Human,Rat

Tested Application ELISA,IHC,WB

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingKEAP1 antibody at dilution of 1:100

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab04517(KEAP1 antibody) at dilution of 1:500

Protein Information

Gene ID9817

Uniprot ID Q14145

Calculated MW

location

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