Anti-MMS19 antibody

$275.00

  • Model: PAab05249
  • 50 Units in Stock
Ask a question


Add to Cart:

Anti-MMS19 antibody

Product Name Anti-MMS19 antibody

Catalog No PAab05249

Packing 100ug

Form liquid

Alternative Name MMS19L

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Immunogen MMS19 nucleotide excision repair homolog (S. cerevisiae)

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IF,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human cervical cancer usingMMS19 antibody at dilution of 1:50

WB use

Protein Information

Gene ID64210

Uniprot ID Q96T76

Calculated MW

location

No customer comments for the moment.

Add A Comment

Related Products

Cart  

No products

Total $0.00

Prices don't include postage.

Cart