Anti-NR1H3 antibody

$275.00

  • Model: PAab05836
  • 50 Units in Stock
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Anti-NR1H3 antibody

Product Name Anti-NR1H3 antibody

Catalog No PAab05836

Packing 100ug

Form liquid

Alternative Name LXRA

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).

Immunogen nuclear receptor subfamily 1, group H, member 3

Specificity Human, Rat

Tested Application ELISA,WB,IF

Recommended dilution

IHC use

WB use

Protein Information

Gene ID10062

Uniprot ID Q13133

Calculated MW

location

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