Anti-NR2F6 antibody

$275.00

  • Model: PAab05845
  • 50 Units in Stock
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Anti-NR2F6 antibody

Product Name Anti-NR2F6 antibody

Catalog No PAab05845

Packing 100ug

Form liquid

Alternative Name EAR2 antibody, ERBAL2

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG2a

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Immunogen nuclear receptor subfamily 2, group F, member 6

Specificity Human, Mouse

Tested Application ELISA,WB,IHC

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human kidney usingNR2F6 antibody at dilution of 1:50

WB use

MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab05845( NR2F6 Antibody) at dilution of 1:1000

Protein Information

Gene ID2063

Uniprot ID P10588

Calculated MW

location

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