Anti-P21 antibody

$275.00

  • Model: PAab06066
  • 50 Units in Stock
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Anti-P21 antibody

Product Name Anti-P21 antibody

Catalog No PAab06066

Packing 100ug

Form liquid

Alternative Name CAP20 antibody, CDK interacting protein 1 antibody, CDKN1 antibody, CDKN1A antibody, CIP1 antibody, MDA 6 antibody, MDA6 antibody, P21 antibody, p21CIP1 antibody, PIC1 antibody, SDI1 antibody, WAF1

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

CDKN1A (p21, CIP1, WAF1), a cyclin-dependent kinase inhibitor, is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.

Immunogen cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Specificity Human,Mouse , Monkey

Tested Application ELISA,WB

Recommended dilution WB:1:500-1:5000

IHC use

WB use

MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab06066( P21 Antibody) at dilution of 1:1000

Protein Information

Gene ID1026

Uniprot ID P38936

Calculated MW 21kDa

location

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