Anti-PD-L1/CD274 antibody


  • Model: PAab06281
  • 50 Units in Stock
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Anti-PD-L1/CD274 antibody

Product Name Anti-PD-L1/CD274 antibody

Catalog No PAab06281

Packing 100ug

Form liquid

Alternative Name B7 H antibody, B7 H1 antibody, B7 homolog 1 antibody, B7H1 antibody, CD274 antibody, CD274 molecule antibody, PD L1 antibody, PDCD1 ligand 1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, PD-L1 antibody, PD-L1/CD274 antibody, Programmed death ligand 1

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation (PMID: 18760278; 16493058).?

Immunogen CD274 molecule

Specificity Human, Mouse ,Pig

Tested Application ELISA,WB,IHC

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