Anti-RBPJ antibody

$300.00

  • Model: PAab07196
  • 50 Units in Stock
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Anti-RBPJ antibody

Product Name Anti-RBPJ antibody

Catalog No PAab07196

Packing 100ug

Form liquid

Alternative Name IGKJRB antibody, IGKJRB1 antibody, RBPJK antibody, RBPSUH

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).

Immunogen recombination signal binding protein for immunoglobulin kappa J region

Specificity Human

Tested Application ELISA,WB

Recommended dilution

IHC use

WB use

Protein Information

Gene ID3516

Uniprot ID Q06330

Calculated MW

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