Anti-RBPJ antibody
Product Name Anti-RBPJ antibody
Catalog No PAab07196
Packing 100ug
Form liquid
Alternative Name IGKJRB antibody, IGKJRB1 antibody, RBPJK antibody, RBPSUH
Purification Protein A+G purification
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
Immunogen recombination signal binding protein for immunoglobulin kappa J region
Specificity Human
Tested Application ELISA,WB
Recommended dilution
IHC use
WB use
Protein Information
Gene ID3516
Uniprot ID Q06330
Calculated MW
location