Anti-USP13 antibody

$300.00

  • Model: PAab09309
  • 50 Units in Stock
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Anti-USP13 antibody

Product Name Anti-USP13 antibody

Catalog No PAab09309

Packing 100ug

Form liquid

Alternative Name Deubiquitinating enzyme 13 antibody, Isopeptidase T 3 antibody, IsoT 3 antibody, ISOT3 antibody, Ubiquitin thiolesterase 13 antibody, USP13

Purification Protein A+G purification

Purity 95% as determined by SDS-PAGE

Host Mouse

Isotype IgG1

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.

Immunogen ubiquitin specific peptidase 13 (isopeptidase T-3)

Specificity Human

Tested Application ELISA,WB,IHC,IF

Recommended dilution WB : 1:500-1:5000;IHC:1:20-1:200;IF:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human testis tissue slide using USP13 Antibody at dilution of 1:200

WB use

HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09309( USP13 Antibody) at dilution of 1:1000

Protein Information

Gene ID8975

Uniprot ID Q92995

Calculated MW 97kDa

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