Anti- Asprosin Antibody (Human)

$596.00

  • Model: PA-RA-90005h
  • 20 Units in Stock
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Anti-Asprosin Antibody

Product name

Anti-Asprosin Antibody

Size

100μg

Form

liquid

Purify

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 ,

-20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background(FUNCTION)

Asprosin is a protein hormone that has been found to be produced by white adipose tissue in mammals; it is transported to the liver, where it stimulates the release of glucose into the blood stream, via a cAMP-dependent pathway.

Glucose released by the liver into the blood stream is required for the normal function of the brain and other organs, as well as for survival during fasting and other aspects of mammalian function.People with Marfan lipodystrophy syndrome are deficient in asprosin, while people presenting the condition of insulin resistance and obesity produce it in abundance.

Discovery and function
Asprosin was first identified by Dr. Atul Chopra and coworkers at Baylor College of Medicine as a C-terminal cleavage product of the FBN1 gene product profibrillin. They found mutations in the FBN1 gene in two patients with congenital partial lipodystrophy and a progeroid appearance.Truncations of the FBN1 protein in these patients were seen to have two consequences for protein production: a mutant/truncated fibrillin protein and very low plasma asprosin levels (from a postulated dominant negative effect).

Therapeutic potential
In a test of pharmacologic asprosin depletion in animals, preliminary results raised the possibility of its use, therapeutically, in treating type 2 diabetes. Specifically, Chopra and coworkers observed that when antibodies targeting asprosin were injected into diabetic mice, blood glucose and insulin levels improved.

Immunogen

Asprosin

Synonyms

ASPRO,Asprosin,FBN1,Fibrillin 1

Specificity

Human,Mouse ,Rat

Tested Application

ELISA,WB,IHC

Recommended dilution

 

IHC testing

Immunohistochemistry of paraffin-embedded liver cancer tissue slide using Asprosin Antibody at dilution of 1:400

WB testing

human brain tissue were subjected to SDS PAGE followed by western blot with Asprosin antibody at dilution of 1:1000

Gene ID

Asprosin

location

Secreted

Entrez

2200

HUGO

3603

OMIM

134797

RefSeq

NP_000129

UniProt

P35555

 
   

Data sheet for Anti-Asprosin Antibody

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Asprosin Protein

Asprosin (ASPRO) Protein, Human

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