Anti-Cdc20 antibody

$275.00

  • Model:  LSMab09997
  • 100 Units in Stock
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Anti-Cdc20 antibody

Product Information
Catalog No.:    LSMab09997
Size:    100μg
Form:    liquid
Purification:    Immunogen affinity purified
Purity:    ≥95% as determined by SDS-PAGE
Host:    Rabbit
IsoType:    IgG
Storage:    PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Immunogen information
Immunogen:    cell division cycle 20 homolog
Synonyms:    CDC20, CDC20A, p55CDC
Calculated MW:    55 kDa
Uniprot ID :    Q12834

Application
Specificity:    Human; other species are not tested. Please decide the specificity by homology
Tested Application:    ELISA, WB, IHC
Recommended dilution:    WB: 1:500-1:2000; IHC: 1:20-1:200

Validation :

     


Immunohistochemistry of paraffin-embedded human colon cancer using LSMab09997(CDC20 antibody) at dilution of 1:100
 

HeLa cells were subjected to SDS PAGE followed by western blot with LSMab09997(CDC20 antibody) at dilution of 1:1000


 

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