Anti-CTNNB1 antibody

$275.00

  • Model:  LSMab09998
  • 100 Units in Stock
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Anti-CTNNB1 antibody

Product Information
Catalog No.:    LSMab09998
Size:    100μg
Form:    liquid
Purification:    Immunogen affinity purified
Purity:    ≥95% as determined by SDS-PAGE
Host:    Rabbit
IsoType:    IgG
Storage:    PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Immunogen information
Immunogen:    catenin(cadherin-associated protein), beta 1, 88kDa
Synonyms:    b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, β catenin, β-catenin
Calculated MW:    90 kDa
Uniprot ID :    P35222

Application
Specificity:    Human, Mouse; other species are not tested. Please decide the specificity by homology
Tested Application:    ELISA, WB, IHC
Recommended dilution:    WB: 1:500-1:2000; IHC: 1:20-1:200


Validation :

     


Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using LSMab09998(CTNNB1 Antibody) at dilution of 1:200
 


mouse heart tissue were subjected to SDS PAGE followed by western blot with LSMab09998(CTNNB1 antibody) at dilution of 1:1000


 

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