Anti-DNMT3A antibody

$245.00

  • Model: PAab02485
  • 50 Units in Stock
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Anti-DNMT3A antibody

 

Product Name Anti-DNMT3A antibody

Catalog No PAab02485

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Immunogen DNA (cytosine-5-)-methyltransferase 3 alpha

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IP

Recommended dilution

IHC use  IHC : 1:20-1:200

Immunohistochemical of paraffin-embedded human heart using DNMT3A antibody at dilution of 1:50

 

Protein Information

Gene ID1788

Uniprot ID Q9Y6K1

Calculated MW  102 kDa

location

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