Anti-EPHA7 antibody

$275.00

  • Model: PAab02805
  • 50 Units in Stock
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Anti-EPHA7 antibody

Product Name Anti-EPHA7 antibody

Catalog No PAab02805

Packing 100ug

Form liquid

Alternative Name EHK3 antibody, HEK11

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Immunogen EPH receptor A7

Specificity Human, Mouse ,Rat

Tested Application ELISA

Recommended dilution

IHC use

WB use

Protein Information

Gene ID2045

Uniprot ID Q15375

Calculated MW

location

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