Anti-ERCC6 antibody
Product Name Anti-ERCC6 antibody
Catalog No PAab02835
Packing 100ug
Form liquid
Alternative Name CSB
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II- blocking lesions.
Immunogen excision repair cross-complementing rodent repair deficiency, complementation group 6
Specificity Human, Mouse ,Rat
Tested Application ELISA,WB
Recommended dilution
IHC use
WB use
Protein Information
Gene ID2074
Uniprot ID Q03468
Calculated MW
location