Anti-FAK antibody

$245.00

  • Model: PAab02950
  • 50 Units in Stock
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Anti-FAK antibody

 

Product Name Anti-FAK antibody

Catalog No PAab02950

Packing 100ug

Form liquid

Alternative Name 
FAK,focal adhesion kinase isoform FAK-Del33; FAK-related non-kinase polypeptide; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK; focal adhesion kinase 1; FADK 1; PTK2 protein tyrosine kinase 2; focal adhesion kinase-related nonkinase; protein phosphatase 1 regulatory subunit 71; protein tyrosine kinase 2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

Immunogen PTK2 protein tyrosine kinase 2

Specificity Human,Mouse ,Rat

Tested Application ELISA,IHC,IP,WB

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human gliomas usingFAK antibody at dilution of 1:100

WB use

MCF7 cells were subjected to SDS PAGE followed by western blot with PAab02950(FAK antibody) at dilution of 1:2000

anti-FAK-antibody west blot

Protein Information

Gene ID 5747

Uniprot ID  Q05397

Calculated MW  119 kDa

location   Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

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