Anti-IPO13 antibody
Product Name Anti-IPO13 antibody
Catalog No PAab04374
Packing 100ug
Form liquid
Alternative Name KIAA0724 antibody, RANBP13
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Immunogen importin 13
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IF
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human gliomas usingIPO13 antibody at dilution of 1:50
WB use
human brain tissue were subjected to SDS PAGE followed by western blot with PAab04374(IPO13 antibody) at dilution of 1:500
Protein Information
Gene ID9670
Uniprot ID O94829
Calculated MW
location