Anti-KPNA5 antibody

$275.00

  • Model: PAab04637
  • 50 Units in Stock
Ask a question


Add to Cart:

Anti-KPNA5 antibody

 

Product Name Anti-KPNA5 antibody

Catalog No PAab04637

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Immunogen karyopherin alpha 5 (importin alpha 6)

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution

WB : 1:1000-1:4000

WB use 

Jurkat cells were subjected to SDS PAGE followed by western blot with KPNA5 antibody at dilution of 1:2000 incubated at room temperature for 1.5 hours

Protein Information

Gene ID3841

Uniprot ID O15131

Calculated MW

location

No customer comments for the moment.

Add A Comment

Related Products

Cart  

No products

Total $0.00

Prices don't include postage.

Cart