Anti-LONP1 antibody
Product Name Anti-LONP1 antibody
Catalog No PAab04820
Packing 100ug
Form liquid
Alternative Name PRSS15
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.
Immunogen lon peptidase 1, mitochondrial
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IHC,IP,IF
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using LONP1 Antibody at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA bufferpH9).
WB use
HeLa cells were subjected to SDS PAGE followed by western blot with PAab04820(LONP1 antibody) at dilution of 1:500
Protein Information
Gene ID9361
Uniprot ID P36776
Calculated MW
location