Anti-MAP4K2 antibody

$275.00

  • Model: PAab04981
  • 50 Units in Stock
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Anti-MAP4K2 antibody

 

Product Name Anti-MAP4K2 antibody

Catalog No PAab04981

Packing 100ug

Form liquid

Alternative Name GCK antibody, RAB8IP

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.

Immunogen mitogen-activated protein kinase kinase kinase kinase 2

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution

WB use  WB : 1:200-1:500

Mouse brain tissue were subjected to SDS PAGE followed by western blot with Anti-MAP4K2 antibody at dilution of 1:300 incubated at room temperature for 1.5 hours.

Protein Information

Gene ID5871

Uniprot ID Q12851

Calculated MW

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