Anti-MDC1 antibody

Product Name Anti-MDC1 antibody

Catalog No PAab05072

Packing 100ug

Form liquid

Alternative Name KIAA0170 antibody, NFBD1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Immunogen mediator of DNA damage checkpoint 1

Specificity Human

Tested Application ELISA,IHC,IF

Recommended dilution

IHC use

WB use

Protein Information

Gene ID9656

Uniprot ID Q14676

Calculated MW

location