Anti-NEUROD1 antibody

$245.00

  • Model: PAab05674
  • 50 Units in Stock
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Anti-NEUROD1 antibody

 

Product Name Anti-NEUROD1 antibody

Catalog No PAab05674

Packing 100ug

Form liquid

Alternative Name BHLHA3 antibody, NEUROD

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Immunogen neurogenic differentiation 1

Specificity Human,Mouse ,Rat

Tested Application ELISA,IHC,WB,IP

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingNEUROD1 antibody at dilution of 1:50

WB use

Y79 cells were subjected to SDS PAGE followed by western blot with PAab05674(NEUROD1 antibody) at dilution of 1:200

Protein Information

Gene ID4760

Uniprot ID Q13562

Calculated MW 50kDa

location

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