Anti-PDK2 antibody

$245.00

  • Model: PAab06277
  • 50 Units in Stock
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Anti-PDK2 antibody

 

Product Name Anti-PDK2 antibody

Catalog No PAab06277

Packing 100ug

Form liquid

Alternative Name PDHK2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Immunogen pyruvate dehydrogenase kinase, isozyme 2

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IP  WB : 1:500-1:2400, IHC : 1:100-1:600

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human brain usingPDK2 antibody at dilution of 1:100

WB use

human heart tissue were subjected to SDS PAGE followed by western blot with PAab06277(PDK2 antibody) at dilution of 1:500

 

Protein Information

Gene ID5164

Uniprot ID Q15119

Calculated MW 46 kd

location Mitochondrion

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