Anti-REST antibody

$300.00

  • Model: PAab07244
  • 50 Units in Stock
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Anti-REST antibody

Product Name Anti-REST antibody

Catalog No PAab07244

Packing 100ug

Form liquid

Alternative Name NRSF antibody, XBR

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Immunogen RE1-silencing transcription factor

Specificity Human

Tested Application ELISA,WB,IP

Recommended dilution

IHC use

WB use

Protein Information

Gene ID5978

Uniprot ID Q13127

Calculated MW

location

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