Anti-RFWD3 antibody

$275.00

  • Model: PAab07257
  • 50 Units in Stock
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Anti-RFWD3 antibody

Product Name Anti-RFWD3 antibody

Catalog No PAab07257

Packing 100ug

Form liquid

Alternative Name RNF201

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Immunogen ring finger and WD repeat domain 3

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IHC,IF

Recommended dilution

IHC use

Immunohistochemistry of paraffin-embedded human testis usingRFWD3 antibody at dilution of 1:400

WB use

mouse lung tissue were subjected to SDS PAGE followed by western blot with PAab07257(RFWD3 antibody) at dilution of 1:1000

Protein Information

Gene ID55159

Uniprot ID Q6PCD5

Calculated MW

location

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